Considering the contents, analyze the following statements about the distribution of agents in the body:

I - Substances penetrate the body and are transported to various regions through the blood and lymph. Some are removed by the lymph and transported through tissues such as those in the lung, through cells such as Come R.
II - The adipose tissue is highly irrigated and therefore suffers more effects.
III - The volume of distribution is a toxicokinetic parameter that indicates the extent of distribution of a substance.
IV - Some factors can interfere with distribution, such as the oil/water partition coefficient of each substance.
V - Placental barriers limit the distribution of substances.
a) I, II, III, IV and V are correct.
b) I, II, III and IV are correct.
c) II, III and IV are correct.
d) III and IV are correct.
e) I and V are correct.