What is the mechanism of action of Levodopa in the treatment of Parkinson's disease? I - Levodopa is an analog of dopamine that is metabolized by ...
What is the mechanism of action of Levodopa in the treatment of Parkinson's disease?
I - Levodopa is an analog of dopamine that is metabolized by the enzyme DOPA decarboxylase and transformed into dopamine.
II - Dopamine is degraded by the enzymes MAO and COMT.
III - Levodopa is used in combination with Carbidopa/Benserazide to inhibit peripheral L-DOPA and increase the amount that reaches the CNS.
IV - Levodopa acts directly on dopamine receptors, without the need for neurons to have an effect.
a) I and II are correct.
b) II and III are correct.
c) I, II, and III are correct.
d) I, II, III, and IV are correct.
I - Levodopa is an analog of dopamine that is metabolized by the enzyme DOPA decarboxylase and transformed into dopamine.
II - Dopamine is degraded by the enzymes MAO and COMT.
III - Levodopa is used in combination with Carbidopa/Benserazide to inhibit peripheral L-DOPA and increase the amount that reaches the CNS.
IV - Levodopa acts directly on dopamine receptors, without the need for neurons to have an effect.
a) I and II are correct.
b) II and III are correct.
c) I, II, and III are correct.
d) I, II, III, and IV are correct.
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Ed 
O mecanismo de ação da Levodopa no tratamento da doença de Parkinson é o seguinte: I - Levodopa é um análogo da dopamina que é metabolizado pela enzima DOPA descarboxilase e transformado em dopamina. II - A dopamina é degradada pelas enzimas MAO e COMT. III - Levodopa é usada em combinação com Carbidopa/Benserazida para inibir a L-DOPA periférica e aumentar a quantidade que chega ao SNC. IV - Levodopa age diretamente nos receptores de dopamina, sem a necessidade de neurônios para ter efeito. A alternativa correta é a letra c) I, II e III estão corretas.
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