What are the clinical aspects of the disease caused by E. histolytica? The disease can range from asymptomatic forms to invasive intestinal amebia...

What are the clinical aspects of the disease caused by E. histolytica?

The disease can range from asymptomatic forms to invasive intestinal amebiasis with dysentery, colitis, appendicitis, megacolon, peritonitis, hepatic abscess, pleuropulmonary abscess, ocular and genital lesions.
The onset of the disease occurs when E. histolytica trophozoites adhere to the epithelial cells of the colon, probably through a specific lectin, galactose/N-acetylgalactosamine (Gal/GalNAc), which recognizes the molecules of these sugars present on the surface of epithelial cells.
Cells of mammals without these sugars are resistant to the adhesion of the amoeba trophozoite, showing its role in adhesion and the known need for parasite-cell contact for the process of cell death.
The parasite invades and damages the tissue through a sequence of events involving multiple factors related to both the parasite and the host.