<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/911cf36a-b7a8-4a79-9eb7-3a2a3ac1260c/bg1.png" alt="Pré-visualização de imagem de arquivo"><div class="c x0 y0 w0 h2"><div class="t m0 x1 h3 y1 ff1 fs0 fc0 sc0 ls12 ws24">Brendha F. Pedro<span class="ff2 ls0">!<span class="ff1">i #85 MedPuc-PR</span></span></div></div><div class="t m0 x2 h4 y2 ff3 fs1 fc0 sc0 ls12 ws0">28/08/20<span class="blank"> </span><span class="ff4 ws1 v1"><span class="fc5 sc0">Enzi</span><span class="fc5 sc0">m</span><span class="fc5 sc0">a</span><span class="fc5 sc0">s</span></span><span class="ws24 v1"><span class="fc5 sc0"> </span></span></div><div class="t m0 x3 h5 y3 ff5 fs1 fc0 sc0 ls13 ws2"><span class="fc5 sc0">In</span><span class="fc5 sc0">t</span><span class="blank"> </span><span class="fc5 sc0">r</span><span class="blank"> </span><span class="fc5 sc0">o</span><span class="fc5 sc0">d</span><span class="blank"> </span><span class="fc5 sc0">u</span><span class="blank"> </span><span class="fc5 sc0">ç</span><span class="blank"> </span><span class="fc5 sc0">ã</span><span class="blank"> </span><span class="fc5 sc0">o</span><span class="blank"> </span><span class="ff3 ls12 ws24"><span class="fc5 sc0"> </span></span></div><div class="t m0 x2 h5 y4 ff3 fs1 fc0 sc0 ls12 ws24"><span class="fc5 sc0">Enzimas: moléculas de prot</span><span class="blank _0"></span><span class="fc5 sc0">eínas altament</span><span class="blank _0"></span><span class="fc5 sc0">e especializadas </span></div><div class="t m0 x2 h5 y5 ff3 fs1 fc0 sc0 ls12 ws24"><span class="fc5 sc0">com poder catalítico </span></div><div class="t m0 x2 h5 y6 ff3 fs1 fc0 sc0 ls12 ws24"><span class="fc5 sc0">Nomenclatura: -ase</span></div><div class="t m0 x3 h5 y7 ff3 fs1 fc0 sc0 ls12 ws24">Reações: quebra, sínt<span class="blank _0"></span>ese, dupla-troca, etc</div><div class="t m0 x3 h5 y8 ff6 fs1 fc1 sc0 ls12 ws24">Sítio Ativo:<span class="ff3 fc0"> local onde o substrato (molécula sobre qual a </span></div><div class="t m0 x3 h5 y9 ff3 fs1 fc0 sc0 ls12 ws24">enzima age) se liga </div><div class="t m0 x3 h5 ya ff6 fs1 fc1 sc0 ls12 ws24">Energia de Ativação:<span class="ff3 fc0"> energia necessária para o substrato </span></div><div class="t m0 x3 h5 yb ff3 fs1 fc0 sc0 ls12 ws24">ficar em seu estado ativado</div><div class="t m0 x3 h5 yc ff3 fs1 fc0 sc0 ls12 ws24">Algumas enzimas necessitam de um component<span class="blank _0"></span>e químico </div><div class="t m0 x3 h5 yd ff3 fs1 fc0 sc0 ls12 ws24">adicional (<span class="ff6 fc2 ws3">cofator</span>)</div><div class="t m0 x3 h5 ye ff3 fs1 fc0 sc0 ls12 ws24">-> pode ser um ou mais íons inorgânicos</div><div class="t m0 x3 h5 yf ff3 fs1 fc0 sc0 ls12 ws24">-> se o cofator for uma molécula orgânica = denominado </div><div class="t m0 x3 h5 y10 ff6 fs1 fc2 sc0 ls12 ws4">coenzima<span class="blank"> </span><span class="fs2 fc3 ws24 v2">agem como carreadores transitórios </span></div><div class="t m0 x4 h6 y11 ff6 fs2 fc3 sc0 ls12 ws24">de grupos funcionais específicos </div><div class="t m0 x5 h6 y12 ff6 fs2 fc3 sc0 ls12 ws24">derivam de vitaminas</div><div class="t m0 x6 h5 y13 ff6 fs1 fc1 sc0 ls12 ws24">Grupo prostético:<span class="ff3 fc0"> coenzima ou íon metálico que se liga </span></div><div class="t m0 x6 h5 y14 ff3 fs1 fc0 sc0 ls12 ws24">muito firmement<span class="blank _0"></span>e a uma enzima</div><div class="t m0 x7 h7 y15 ff6 fs3 fc0 sc0 ls12 ws24">ou covalent<span class="blank _0"></span>emente</div><div class="t m0 x2 h5 y16 ff6 fs1 fc1 sc0 ls12 ws3">Holoenzima:<span class="ff3 fc0 ws24"> enzima completa, cataliticament<span class="blank _0"></span>e ativa com </span></div><div class="t m0 x2 h5 y17 ff3 fs1 fc0 sc0 ls12 ws24">sua coenzima e/ou íons metálicos</div><div class="t m0 x3 h5 y18 ff6 fs1 fc1 sc0 ls12 ws24">Apoenzima ou Apoprot<span class="blank _0"></span>eína:<span class="ff3 fc0"> part<span class="blank _0"></span>e prot<span class="blank _0"></span>eica da enzima</span></div><div class="t m0 x3 h5 y19 ff3 fs1 fc0 sc0 ls12 ws24">Substrato: molécula que se liga ao sítio ativo da enzima e </div><div class="t m0 x3 h5 y1a ff3 fs1 fc0 sc0 ls12 ws24">sobre a qual a enzima age</div><div class="t m0 x8 h5 y1b ff3 fs1 fc0 sc0 ls12 ws24">Fatores que afetam a a<span class="fc5 sc0">tividade enzimátic</span>a:</div><div class="t m0 x8 h5 y1c ff3 fs1 fc0 sc0 ls12 ws24">-> t<span class="blank _0"></span>emperatura</div><div class="t m0 x8 h5 y1d ff3 fs1 fc0 sc0 ls12 ws24">-> pH</div><div class="t m0 x8 h5 y1e ff3 fs1 fc0 sc0 ls12 ws24">-> concentração de substrato</div><div class="t m0 x9 h5 y1f ff3 fs1 fc0 sc0 ls12 ws24">Velocidade da reação = det<span class="blank _0"></span>erminada pela concentração </div><div class="t m0 x9 h5 y20 ff3 fs1 fc0 sc0 ls12 ws24">de reagent<span class="blank _0"></span>es</div><div class="t m0 x2 h5 y21 ff3 fs1 fc0 sc0 ls12 ws24">Concentração saturant<span class="blank _0"></span>e de substrato: quando a enzima </div><div class="t m0 x2 h5 y22 ff3 fs1 fc0 sc0 ls12 ws24">está cheia de substrato </div><div class="t m0 xa h8 y23 ff5 fs1 fc0 sc0 ls1 ws24">Cinética En<span class="blank _0"></span>zimá<span class="blank _0"></span>tica </div><div class="t m0 x9 h5 y24 ff3 fs1 fc0 sc0 ls12 ws24">Gráfico Michaelis-Ment<span class="blank _0"></span>em</div><div class="t m0 xb h5 y25 ff3 fs1 fc0 sc0 ls12 ws24">Gráfico “duplo-reciproco” ou Lineweaver-Burke</div><div class="t m0 x9 h5 y26 ff6 fs1 fc4 sc0 ls12 ws24">Enzimas alostéricas:<span class="ff3 fc0"> reguladas dentro de uma via meta-</span></div><div class="t m0 x9 h5 y27 ff3 fs1 fc0 sc0 ls12 ws24">bólica por moduladores/efetores (reguladores)</div><div class="t m0 x8 h5 y28 ff6 fs1 fc4 sc0 ls12 ws24">Enzimas michaelianas: <span class="ff3 fc0">reguladas soment<span class="blank _0"></span>e pela concen-</span></div><div class="t m0 x8 h5 y29 ff3 fs1 fc0 sc0 ls12 ws24">tração de substrato</div><div class="t m0 xc h5 y2a ff3 fs1 fc0 sc0 ls12 ws24">*modulador alostérico se liga ao sítio alostérico </div><div class="t m1 x6 h9 y2b ff7 fs4 fc5 sc0 ls12"><span class="fc5 sc0">-</span></div><div class="t m2 xd ha y2c ff7 fs5 fc5 sc0 ls12"><span class="fc5 sc0">°</span></div><div class="t m3 x5 hb y2d ff7 fs6 fc5 sc0 ls12"><span class="fc5 sc0">.</span></div><div class="t m4 xe hc y2e ff7 fs7 fc5 sc0 ls12"><span class="fc5 sc0">*</span></div><div class="t m5 xf hd y2f ff7 fs8 fc5 sc0 ls14 ws5"><span class="fc5 sc0">te</span><span class="fc5 sc0">m</span><span class="fc5 sc0">p</span><span class="fc5 sc0">e</span><span class="fc5 sc0">r</span><span class="blank _1"> </span><span class="fc5 sc0">a</span><span class="fc5 sc0">t</span><span class="fc5 sc0">u</span><span class="fc5 sc0">r</span><span class="fc5 sc0">a</span></div><div class="t m6 x10 he y30 ff7 fs9 fc5 sc0 ls2 ws6"><span class="fc5 sc0">ót</span><span class="fc5 sc0">ima</span></div><div class="t m7 x11 hf y31 ff7 fsa fc5 sc0 ls12"><span class="fc5 sc0">*</span></div><div class="t m8 x12 h10 y32 ff7 fsb fc5 sc0 ls15"><span class="fc5 sc0">pH</span></div><div class="t m9 x13 h11 y33 ff7 fsc fc5 sc0 ls3 ws7"><span class="fc5 sc0">ót</span><span class="fc5 sc0">imo</span></div><div class="t ma x5 h12 y34 ff7 fsd fc5 sc0 ls12"><span class="fc5 sc0">.</span></div><div class="t mb x14 h13 y35 ff8 fse fc5 sc0 ls16"><span class="fc5 sc0">rsaiiiâiiiiiiiii</span></div><div class="t mc x15 h14 y36 ff7 fsf fc5 sc0 ls12"><span class="fc5 sc0">-</span></div><div class="t md xd h15 y37 ff7 fs10 fc5 sc0 ls12"><span class="fc5 sc0">I</span></div><div class="t me xa h16 y38 ff7 fs11 fc5 sc0 ls12"><span class="fc5 sc0">-</span></div><div class="t mf x15 h17 y39 ff7 fs12 fc5 sc0 ls12"><span class="fc5 sc0">\</span></div><div class="t m10 x16 h18 y3a ff7 fs13 fc5 sc0 ls12"><span class="fc5 sc0">*</span></div><div class="t m11 x17 h19 y3b ff7 fs14 fc5 sc0 ls4 ws8"><span class="fc5 sc0">espec</span><span class="fc5 sc0">if</span><span class="fc5 sc0">ic</span><span class="fc5 sc0">ida</span><span class="fc5 sc0">de</span></div><div class="t m12 x18 h1a y3c ff9 fs15 fc5 sc0 ls12"><span class="fc5 sc0">µ</span></div><div class="t m13 x19 h1b y3d ffa fs16 fc5 sc0 ls17"><span class="fc5 sc0">seja</span></div><div class="t m14 x1a h1c y3e ff7 fs17 fc5 sc0 ls5 ws9"><span class="fc5 sc0">tiennida</span><span class="fc5 sc0">dema</span></div><div class="t m15 x1b h1d y3f ff7 fs18 fc5 sc0 ls12"><span class="fc5 sc0">*</span></div><div class="t m16 x1c h1e y40 ff7 fs19 fc5 sc0 ls18"><span class="fc5 sc0">uma</span></div><div class="t m17 x1d h1f y41 ff7 fs1a fc5 sc0 ls6 wsa"><span class="fc5 sc0">ve</span><span class="fc5 sc0">z</span></div><div class="t m18 x1e h20 y42 ff7 fs1b fc5 sc0 ls19"><span class="fc5 sc0">que</span></div><div class="t m19 x1f h21 y43 ff7 fs1c fc5 sc0 ls12"><span class="fc5 sc0">o</span></div><div class="t m1a x20 h22 y44 ff7 fs1d fc5 sc0 ls1a wsb"><span class="fc5 sc0">subs</span><span class="fc5 sc0">tr</span><span class="fc5 sc0">a</span><span class="fc5 sc0">t</span><span class="fc5 sc0">o</span></div><div class="t m1b x21 h23 y45 ff7 fs1e fc5 sc0 ls12"><span class="fc5 sc0">é</span></div><div class="t m1c x22 h24 y46 ff7 fs1f fc5 sc0 ls1b wsc"><span class="fc5 sc0">tr</span><span class="fc5 sc0">a</span><span class="fc5 sc0">nsf</span><span class="fc5 sc0">o</span><span class="fc5 sc0">r</span><span class="fc5 sc0">ma</span><span class="fc5 sc0">do</span></div><div class="t m1d x23 h25 y47 ff7 fs20 fc5 sc0 ls1c"><span class="fc5 sc0">em</span></div><div class="t m1e x24 h26 y48 ff7 fs21 fc5 sc0 ls1d wsd"><span class="fc5 sc0">pr</span><span class="fc5 sc0">o</span><span class="fc5 sc0">dut</span><span class="fc5 sc0">o</span></div><div class="t m1f x25 h27 y49 ff7 fs22 fc5 sc0 ls12"><span class="fc5 sc0">,</span></div><div class="t m20 x26 h28 y4a ff7 fs23 fc5 sc0 ls1e"><span class="fc5 sc0">ele</span></div><div class="t m21 x27 h29 y4b ff7 fs24 fc5 sc0 ls1f wse"><span class="fc5 sc0">per</span><span class="fc5 sc0">de</span></div><div class="t m22 x5 h2a y4c ff7 fs25 fc5 sc0 ls12"><span class="fc5 sc0">,</span></div><div class="t m23 x1b h2b y4d ff7 fs26 fc5 sc0 ls20"><span class="fc5 sc0">sua</span></div><div class="t m24 x28 h2c y4e ff7 fs27 fc5 sc0 ls21 wsf"><span class="fc5 sc0">afin</span><span class="fc5 sc0">id</span><span class="fc5 sc0">ad</span><span class="fc5 sc0">e</span></div><div class="t m25 x29 h2d y4f ff7 fs28 fc5 sc0 ls22"><span class="fc5 sc0">com</span></div><div class="t m26 x2a h2e y50 ff7 fs29 fc5 sc0 ls12"><span class="fc5 sc0">o</span></div><div class="t m27 x14 h2f y51 ff7 fs2a fc5 sc0 ls23"><span class="fc5 sc0">sítio</span></div><div class="t m28 x2b h30 y52 ff7 fs2b fc5 sc0 ls7 ws10"><span class="fc5 sc0">at</span><span class="fc5 sc0">iv</span><span class="fc5 sc0">o</span></div><div class="t m29 x2c h31 y53 ff7 fs2c fc5 sc0 ls24"><span class="fc5 sc0">da</span></div><div class="t m2a x2d h32 y54 ff7 fs2d fc5 sc0 ls25"><span class="fc5 sc0">enzima</span></div><div class="t m2b x23 h33 y55 ff7 fs2e fc5 sc0 ls12"><span class="fc5 sc0">,</span></div><div class="t m2c x2e h34 y56 ff7 fs2f fc5 sc0 ls26"><span class="fc5 sc0">sendo</span></div><div class="t m2d x2f h35 y57 ff7 fs30 fc5 sc0 ls27"><span class="fc5 sc0">liberado</span></div><div class="t m2e x30 h36 y58 ff8 fs31 fc5 sc0 ls28"><span class="fc5 sc0">PÍFIA</span></div><div class="t m2f x31 h37 y59 ff7 fs32 fc5 sc0 ls12"><span class="fc5 sc0">S</span></div><div class="t m30 x21 h38 y5a ff7 fs33 fc5 sc0 ls12"><span class="fc5 sc0">#</span></div><div class="t m31 x32 h39 y5b ffb fs34 fc5 sc0 ls12"><span class="fc5 sc0">↳</span></div><div class="t m32 x33 h3a y5c ff7 fs35 fc5 sc0 ls8 ws11"><span class="fc5 sc0">SUBSTRA</span><span class="blank _0"></span><span class="fc5 sc0">T</span><span class="fc5 sc0">O</span></div><div class="t m33 x34 h3b y5d ff7 fs36 fc5 sc0 ls29 ws12"><span class="fc5 sc0">At</span><span class="fc5 sc0">i</span><span class="blank"> </span><span class="fc5 sc0">v</span><span class="fc5 sc0">a</span><span class="blank"> </span><span class="fc5 sc0">d</span><span class="blank"> </span><span class="fc5 sc0">o</span></div><div class="t m34 x35 h3c y5e ff7 fs37 fc5 sc0 ls2a ws13"><span class="fc5 sc0">SUÍ</span><span class="fc5 sc0">ÇO</span></div><div class="t m35 x36 h3d y5f ff7 fs38 fc5 sc0 ls12"><span class="fc5 sc0">"</span></div><div class="t m36 x37 h3e y60 ff7 fs39 fc5 sc0 ls2b ws14"><span class="fc5 sc0">ptr</span><span class="fc5 sc0">a</span><span class="fc5 sc0">á</span><span class="fc5 sc0">o</span><span class="fc5 sc0">ã</span><span class="fc5 sc0">o</span><span class="fc5 sc0">a</span><span class="fc5 sc0">uedea</span></div><div class="t m37 x38 h3f y61 ff7 fs3a fc5 sc0 ls12"><span class="fc5 sc0">"</span></div><div class="t m38 x39 h40 y62 ff7 fs3b fc5 sc0 ls12"><span class="fc5 sc0">"</span></div><div class="t m39 x3a h41 y63 ff8 fs3c fc5 sc0 ls9 ws15"><span class="fc5 sc0">Í</span><span class="fc5 sc0">ú</span><span class="fc5 sc0">smhii</span><span class="blank _0"></span></div><div class="t m3a x3b h42 y64 ff8 fs3d fc5 sc0 ls2c"><span class="fc5 sc0">a.</span></div><div class="t m3b x3c h43 y65 ffc fs3e fc5 sc0 ls12"><span class="fc5 sc0">⇐</span></div><div class="t m3c x3d h44 y66 ff8 fs3f fc5 sc0 lsa ws16"><span class="fc5 sc0">÷÷i</span><span class="fc5 sc0">÷÷÷÷÷</span></div><div class="t m3d x3e h45 y67 ffd fs40 fc5 sc0 ls12"><span class="fc5 sc0">:</span></div><div class="t m3e x6 h46 y68 ff7 fs41 fc5 sc0 ls12"><span class="fc5 sc0">'</span></div><div class="t m3f x3f h47 y69 ffe fs42 fc5 sc0 ls2d ws17"><span class="fc5 sc0">ei</span><span class="fc5 sc0">t</span><span class="fc5 sc0">a</span></div><div class="t m40 x40 h48 y6a fff fs43 fc5 sc0 ls2e"><span class="fc5 sc0">:*</span></div><div class="t m41 x41 h49 y6b ff10 fs44 fc5 sc0 ls12"><span class="fc5 sc0">:</span></div><div class="t m42 x42 h4a y6c ff11 fs45 fc5 sc0 ls12"><span class="fc5 sc0">:</span></div><div class="t m43 x43 h4b y6d ff8 fs46 fc5 sc0 ls2f ws18"><span class="fc5 sc0">Fa</span><span class="blank"> </span><span class="fc5 sc0">z</span></div><div class="t m44 xf h4c y6e ff8 fs47 fc5 sc0 ls12"><span class="fc5 sc0">O</span></div><div class="t m45 x44 h4d y6f ff12 fs48 fc5 sc0 ls12"><span class="fc5 sc0">/</span></div><div class="t m46 x45 h4e y70 ff7 fs49 fc5 sc0 ls12"><span class="fc5 sc0">"</span></div><div class="t m47 xd h4f y71 ff8 fs4a fc5 sc0 ls12"><span class="fc5 sc0">=</span></div><div class="t m48 x46 h50 y72 ff7 fs4b fc5 sc0 ls12"><span class="fc5 sc0">.</span></div><div class="t m49 x47 h51 y73 ff8 fs4c fc5 sc0 lsb ws19"><span class="fc5 sc0">Ga</span><span class="blank _2"></span><span class="fc5 sc0">zza</span></div><div class="t m4a x48 h52 y74 ff7 fs4d fc5 sc0 ls12"><span class="fc5 sc0">,</span></div><div class="t m4b xd h53 y75 ff7 fs4e fc5 sc0 ls12"><span class="fc5 sc0">-</span></div><div class="t m4c x15 h54 y76 ff7 fs4f fc5 sc0 ls12"><span class="fc5 sc0">-</span></div><div class="t m4d x49 h55 y77 ffb fs50 fc5 sc0 ls12"><span class="fc5 sc0">↳</span></div><div class="t m4e x4a h56 y78 ff8 fs51 fc5 sc0 ls30"><span class="fc5 sc0">B-</span></div><div class="t m4f x4b h57 y79 ff8 fs52 fc5 sc0 ls12"><span class="fc5 sc0">O</span></div><div class="t m50 xd h58 y7a ff7 fs53 fc5 sc0 ls12"><span class="fc5 sc0">-</span></div><div class="t m51 x13 h59 y7b ff8 fs54 fc5 sc0 ls12"><span class="fc5 sc0">o</span></div><div class="t m52 x5 h5a y7c ff7 fs55 fc5 sc0 ls12"><span class="fc5 sc0">\</span></div><div class="t m53 x15 h5b y7d ff13 fs56 fc5 sc0 ls12"><span class="fc5 sc0">:</span></div><div class="t m54 x4c h5c y7e ffb fs57 fc5 sc0 ls12"><span class="fc5 sc0">↳</span></div><div class="t m55 x28 h5d y7f ff7 fs58 fc5 sc0 ls31 ws1a"><span class="fc5 sc0">to</span><span class="fc5 sc0">d</span><span class="fc5 sc0">o</span><span class="fc5 sc0">s</span></div><div class="t m56 x4d h5e y80 ff7 fs59 fc5 sc0 ls32"><span class="fc5 sc0">os</span></div><div class="t m57 x29 h5f y81 ff7 fs5a fc5 sc0 lsc ws1b"><span class="fc5 sc0">sítio</span><span class="fc5 sc0">s</span></div><div class="t m58 x4e h60 y82 ff7 fs5b fc5 sc0 lsd ws1c"><span class="fc5 sc0">at</span><span class="fc5 sc0">iv</span><span class="fc5 sc0">os</span></div><div class="t m59 x4f h61 y83 ff7 fs5c fc5 sc0 lse ws1d"><span class="fc5 sc0">es</span><span class="fc5 sc0">tã</span><span class="fc5 sc0">o</span></div><div class="t m5a x50 h62 y84 ff7 fs5d fc5 sc0 ls33 ws1e"><span class="fc5 sc0">ocu</span><span class="fc5 sc0">p</span><span class="fc5 sc0">ad</span><span class="fc5 sc0">os</span></div><div class="t m5b x51 h63 y85 ff7 fs5e fc5 sc0 ls12"><span class="fc5 sc0">a</span></div><div class="t m5c x52 h64 y86 ff7 fs5f fc5 sc0 ls34 ws1f"><span class="fc5 sc0">to</span><span class="fc5 sc0">d</span><span class="fc5 sc0">o</span></div><div class="t m5d x53 h65 y87 ff7 fs60 fc5 sc0 lsf ws20"><span class="fc5 sc0">moment</span><span class="fc5 sc0">o</span></div><div class="t m5e x54 h66 y88 ffb fs61 fc5 sc0 ls12"><span class="fc5 sc0">↳</span></div><div class="t m5f x11 h67 y89 ff7 fs62 fc5 sc0 ls35 ws21"><span class="fc5 sc0">alg</span><span class="fc5 sc0">u</span><span class="fc5 sc0">é</span><span class="fc5 sc0">m</span></div><div class="t m60 x55 h68 y8a ff7 fs63 fc5 sc0 ls10 ws22"><span class="fc5 sc0">pr</span><span class="fc5 sc0">ec</span><span class="fc5 sc0">isa</span></div><div class="t m61 x56 h69 y8b ff7 fs64 fc5 sc0 ls11 ws23"><span class="fc5 sc0">afir</span><span class="fc5 sc0">mar</span></div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi x0 y0 w1 h1" alt src="https://files.passeidireto.com/911cf36a-b7a8-4a79-9eb7-3a2a3ac1260c/bg2.png" alt="Pré-visualização de imagem de arquivo"><div class="c x0 y0 w0 h2"><div class="t m0 x1 h3 y1 ff1 fs0 fc0 sc0 ls12 ws24">Brendha F. Pedro<span class="ff2 ls0">!<span class="ff1">i #85 MedPuc-PR</span></span></div></div><div class="t m0 x3 h5 y8c ff5 fs1 fc0 sc0 ls1 ws24">En<span class="blank _0"></span>zimas de I<span class="blank _0"></span>nter<span class="blank _0"></span>esse Clínico<span class="ff3 ls12"> </span></div><div class="t m0 x2 h5 y8d ff3 fs1 fc0 sc0 ls12 ws24"> </div><div class="t m0 x57 h6a y8e ff5 fs1 fc0 sc0 ls39 ws24">> <span class="ff14 fc1 ls12">I<span class="blank _0"></span>nibição Rev<span class="blank _0"></span>ersíve<span class="blank _0"></span>l: Não-C<span class="ff15"></span>petiti<span class="blank _0"></span>va </span></div><div class="t m0 x58 h6a y8f ff5 fs1 fc0 sc0 ls39 ws24">> <span class="ff14 fc1 ls12">I<span class="blank _0"></span>nibição Rev<span class="blank _0"></span>ersíve<span class="blank _0"></span>l: C<span class="ff15"></span>petitiv<span class="blank _0"></span>a </span></div><div class="t m0 x3 h8 y90 ff5 fs1 fc0 sc0 ls13 ws2">In<span class="blank"> </span>ibi<span class="blank"> </span>d<span class="blank"> </span><span class="ff16 ls36"><span class="ff5 ws24">es e Inib<span class="blank _0"></span>ições </span></span></div><div class="t m0 x5 h5 y91 ff6 fs1 fc4 sc0 ls12 ws3">Zimogênio:<span class="fc0 ws24"> uma enzima que está pronta, mas não está ativa</span></div><div class="t m0 x4c h5 y92 ff6 fs1 fc0 sc0 ls12 ws24">*apresenta um espaço a mais em sua estrutura que </div><div class="t m0 x59 h5 y93 ff6 fs1 fc0 sc0 ls12 ws24">recobre o sítio ativo ou que faz com que ela adquira uma </div><div class="t m0 x5a h5 y94 ff6 fs1 fc0 sc0 ls12 ws24">conformação que esconda seu sítio ativo</div><div class="t m0 x3 h5 y95 ff6 fs1 fc0 sc0 ls12 ws24">*sofre uma clivagem prot<span class="blank _0"></span>eolítica, perdendo um pedaço de </div><div class="t m0 x57 h5 y96 ff6 fs1 fc0 sc0 ls12 ws24">sua estrutura e expondo o sítio ativo (tornando-se ativa)</div><div class="t m0 x3 h5 y97 ff6 fs1 fc6 sc0 ls12 ws24">ex: enzima digestiva</div><div class="t m0 x3 h5 y98 ff3 fs1 fc0 sc0 ls12 ws24">Enzimas específicas de um órgão podem auxiliar no </div><div class="t m0 x3 h5 y99 ff3 fs1 fc0 sc0 ls12 ws24">diagnóstico clínico </div><div class="t m0 x2 h5 y9a ff3 fs1 fc0 sc0 ls12 ws24">ex: hepatit<span class="blank _0"></span>e = fígado comprometido </div><div class="t m0 x3 h5 y9b ff3 fs1 fc0 sc0 ls12 ws24">inflamação das células hepáticas -> lise celular dos </div><div class="t m0 x3 h5 y9c ff3 fs1 fc0 sc0 ls12 ws24">hepatocitos -> vão para o meio extracelular -> vão </div><div class="t m0 x3 h5 y9d ff3 fs1 fc0 sc0 ls12 ws24">para a corrent<span class="blank _0"></span>e sanguínea </div><div class="t m0 x2 h5 y9e ff3 fs1 fc0 sc0 ls12 ws24">Inibidores: </div><div class="t m0 x2 h5 y9f ff3 fs1 fc0 sc0 ls12 ws24">-> Reversíveis: inibição competitiva e inibição não-</div><div class="t m0 x2 h5 ya0 ff3 fs1 fc0 sc0 ls12 ws24">competitiva </div><div class="t m0 x2 h5 ya1 ff3 fs1 fc0 sc0 ls12 ws24">-> Irreversíveis </div><div class="t m0 x5b h5 ya2 ff3 fs1 fc0 sc0 ls12 ws24">Competição pelo sítio ativo da enzima </div><div class="t m0 x5c h5 ya3 ff6 fs1 fc0 sc0 ls12 ws24">Sítio ativo </div><div class="t m0 x5c h5 ya4 ff6 fs1 fc0 sc0 ls12 ws24">da enzima </div><div class="t m0 x5d h6b ya5 ff3 fs65 fc0 sc0 ls12 ws24">liga-se ao<span class="blank _3"> </span><span class="fs1 v3">substrato </span></div><div class="t m0 x22 h5 ya6 ff3 fs1 fc0 sc0 ls12 ws24">inibidor </div><div class="t m0 x5e h5 ya7 ff3 fs1 fc0 sc0 ls12 ws24">=> reação acont<span class="blank _0"></span>ece</div><div class="t m0 x5f h5 ya8 ff3 fs1 fc0 sc0 ls12 ws24">=> reação não acont<span class="blank _0"></span>ece</div><div class="t m0 x58 h5 ya9 ff3 fs1 fc0 sc0 ls12 ws24">Revert<span class="blank _0"></span>er a inibição = aumentando a concentração do </div><div class="t m0 x58 h5 yaa ff3 fs1 fc0 sc0 ls12 ws24">substrato </div><div class="t m0 x60 h5 yab ff3 fs1 fc0 sc0 ls12 ws24">Na presença do inibidor, a relação de afinidade entre </div><div class="t m0 x60 h5 yac ff3 fs1 fc0 sc0 ls12 ws24">enzima e substrato mudam -> muda K (= K )</div><div class="t m0 x58 h5 yad ff3 fs1 fc0 sc0 ls12 ws24">V não se alt<span class="blank _0"></span>era</div><div class="t m0 x1c h5 yae ff3 fs1 fc0 sc0 ls12 ws24">Exemplo de inibidores competitivos: medicamentos </div><div class="t m0 x5b h5 yaf ff3 fs1 fc0 sc0 ls12 ws24">Inibidor pode se ligar na enzima mesmo com o substrato </div><div class="t m0 x58 h5 yb0 ff3 fs1 fc0 sc0 ls12 ws24">Inibidor atrapalha o t<span class="blank _0"></span>empo todo</div><div class="t m0 x60 h5 yb1 ff3 fs1 fc0 sc0 ls12 ws24">A partir do momento em que o inibidor se liga, n<span class="fc5 sc0">ã</span>o há a </div><div class="t m0 x60 h5 yb2 ff3 fs1 fc0 sc0 ls12 ws24">formação de produto </div><div class="t m0 x58 h5 yb3 ff3 fs1 fc0 sc0 ls12 ws24"><span class="fc5 sc0">K se mantém </span></div><div class="t m0 x58 h5 yb4 ff3 fs1 fc0 sc0 ls12 ws24"><span class="fc5 sc0">V se alt</span><span class="blank _0"></span><span class="fc5 sc0">era</span></div><div class="t m62 x61 h6c yb5 ff17 fs66 fc5 sc0 ls12">A</div><div class="t m63 x62 h6d yb6 ffb fs67 fc5 sc0 ls12">↳</div><div class="t m64 x6 h6e yb7 ff7 fs68 fc5 sc0 ls12">-</div><div class="t m65 x3d h6f yb8 ff7 fs69 fc5 sc0 ls3a">sem</div><div class="t m66 x15 h70 yb9 ff7 fs6a fc5 sc0 ls12">-</div><div class="t m67 x63 h71 yba ff7 fs6b fc5 sc0 ls3b">inibidor</div><div class="t m68 x6 h72 ybb ff7 fs6c fc5 sc0 ls12">-</div><div class="t m69 x6 h73 ybc ff7 fs6d fc5 sc0 ls12">I</div><div class="t m6a x64 h74 ybd ff7 fs6e fc5 sc0 ls12">-</div><div class="t m6b x1f h75 ybe ff18 fs6f fc5 sc0 ls12">-</div><div class="t m6c x1f h76 ybf ff7 fs70 fc5 sc0 ls12">-</div><div class="t m6d x57 h77 yc0 ff19 fs71 fc5 sc0 ls12">:</div><div class="t m6e x65 h78 yc1 ff7 fs72 fc5 sc0 ls12">m</div><div class="t m6f x66 h79 yc2 ff7 fs73 fc5 sc0 ls12">m</div><div class="t m70 x67 h7a yc3 ff7 fs74 fc5 sc0 ls3c ws25">aparente</div><div class="t m71 x57 h7b yc4 ff7 fs75 fc5 sc0 ls12">"</div><div class="t m72 x1c h7c yc5 ff7 fs76 fc5 sc0 ls3d">máx</div><div class="t m73 x64 h7d yc6 ff7 fs77 fc5 sc0 ls12">-</div><div class="t m74 x57 h7e yc7 ff7 fs78 fc5 sc0 ls12">-</div><div class="t m75 x60 h7f yc8 ff7 fs79 fc5 sc0 ls12">*</div><div class="t m76 x68 h80 yc9 ff7 fs7a fc5 sc0 ls3e">liga</div><div class="t m77 x69 h81 yca ff7 fs7b fc5 sc0 ls12">-</div><div class="t m78 x6a h82 ycb ff7 fs7c fc5 sc0 ls3f">se</div><div class="t m79 x5a h83 ycc ff7 fs7d fc5 sc0 ls40">em</div><div class="t m7a x1e h84 ycd ff7 fs7e fc5 sc0 ls41">um</div><div class="t m7b x6b h85 yce ff7 fs7f fc5 sc0 ls37 ws26">lugar</div><div class="t m7c x6c h86 ycf ff7 fs80 fc5 sc0 ls38 ws27">diferente</div><div class="t m7d x31 h87 yd0 ff7 fs81 fc5 sc0 ls42">da</div><div class="t m7e x22 h88 yd1 ff7 fs82 fc5 sc0 ls43">enzima</div><div class="t m7f x57 h89 yd2 ff7 fs83 fc5 sc0 ls12">/</div><div class="t m80 x59 h8a yd3 ff8 fs84 fc5 sc0 ls12">:</div><div class="t m81 x57 h8b yd4 ff7 fs85 fc5 sc0 ls12">"</div><div class="t m82 x68 h8c yd5 ff7 fs86 fc5 sc0 ls44">máx</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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