What are the physiological barriers that influence drug distribution? Permeability capillary Hematoencephalic barrier Placenta Testicular barrier I...
What are the physiological barriers that influence drug distribution?
Permeability capillary
Hematoencephalic barrier
Placenta
Testicular barrier
I- The chemical structure of a substance affects its ability to cross cell membranes.
II- Hydrophobic drugs easily pass through most biological membranes.
III- Hydrophilic drugs easily move in the interstitial fluid.
IV- The blood-brain barrier is formed by endothelial cells that have intracellular pores and pinocytic vesicles.
V- The placenta allows the passage of potentially harmful substances from the maternal bloodstream to the fetus.
VI- The hematotesticular barrier is a highly selective permeability barrier formed by Sertoli cells that separates the interstitial space from the seminiferous tubules of the testicles.
a) I, II, IV, and VI are correct.
b) II, III, and V are correct.
c) I, II, III, V, and VI are correct.
d) I, III, IV, and V are correct.
Permeability capillary
Hematoencephalic barrier
Placenta
Testicular barrier
I- The chemical structure of a substance affects its ability to cross cell membranes.
II- Hydrophobic drugs easily pass through most biological membranes.
III- Hydrophilic drugs easily move in the interstitial fluid.
IV- The blood-brain barrier is formed by endothelial cells that have intracellular pores and pinocytic vesicles.
V- The placenta allows the passage of potentially harmful substances from the maternal bloodstream to the fetus.
VI- The hematotesticular barrier is a highly selective permeability barrier formed by Sertoli cells that separates the interstitial space from the seminiferous tubules of the testicles.
a) I, II, IV, and VI are correct.
b) II, III, and V are correct.
c) I, II, III, V, and VI are correct.
d) I, III, IV, and V are correct.
💡 1 Resposta
Ed 
A resposta correta é a alternativa d) I, III, IV e V estão corretas. As barreiras fisiológicas que influenciam a distribuição de medicamentos são: I- A estrutura química de uma substância afeta sua capacidade de atravessar as membranas celulares. III- Medicamentos hidrofílicos movem-se facilmente no fluido intersticial. IV- A barreira hematoencefálica é formada por células endoteliais que possuem poros intracelulares e vesículas pinocíticas. V- A placenta permite a passagem de substâncias potencialmente prejudiciais da corrente sanguínea materna para o feto. Espero ter ajudado!
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