What are the characteristics of phase 1 and phase 2 drug metabolism?
a. Phase 1 reactions produce changes in the molecular structure of the drug, w...
What are the characteristics of phase 1 and phase 2 drug metabolism? a. Phase 1 reactions produce changes in the molecular structure of the drug, while phase 2 reactions add endogenous compounds to the product of phase 1 to make it less liposoluble and more easily excreted. b. Phase 1 reactions are carried out by microsomal and non-microsomal oxidations and reductions, while phase 2 reactions involve the addition of hydrophilic compounds to the product of phase 1. c. Phase 1 reactions are predictable and produce inactive metabolites, while phase 2 reactions are varied and produce active metabolites. d. Phase 1 reactions are carried out by microsomal and non-microsomal hydrolysis, while phase 2 reactions involve the addition of lipophilic compounds to the product of phase 1.
A alternativa correta é a letra B. Nas reações da fase 1, ocorrem oxidações e reduções microsomais e não microsomais, enquanto nas reações da fase 2, há a adição de compostos hidrofílicos ao produto da fase 1.
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