Referring to the discipline of MEDICINAL CHEMISTRY, answer the following questions: What is NOT a result of introducing rings into a prototype comp...
Referring to the discipline of MEDICINAL CHEMISTRY, answer the following questions:
What is NOT a result of introducing rings into a prototype compound?
What is the correct description of the main function of drug metabolism?
The introduction of rings in a prototype compound can improve interaction with the receptor site, introduce rigidity into the molecule, increase the half-life of a molecule, prevent steric access to metabolism sites, and make the molecule more flexible.
Drug metabolism modifies the chemical structure of drugs to make them more lipophilic, form metabolites with lower lipophilicity, modify the structure of drugs into more polar and hydrophilic metabolites, cause pharmacodynamic modifications in inactive drugs, and generate structural modifications in the drug, forming active and often toxic metabolites to the organism.
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What is NOT a result of introducing rings into a prototype compound?
What is the correct description of the main function of drug metabolism?
The introduction of rings in a prototype compound can improve interaction with the receptor site, introduce rigidity into the molecule, increase the half-life of a molecule, prevent steric access to metabolism sites, and make the molecule more flexible.
Drug metabolism modifies the chemical structure of drugs to make them more lipophilic, form metabolites with lower lipophilicity, modify the structure of drugs into more polar and hydrophilic metabolites, cause pharmacodynamic modifications in inactive drugs, and generate structural modifications in the drug, forming active and often toxic metabolites to the organism.
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Ed 
A introdução de anéis em um composto protótipo NÃO pode resultar em prejuízo à interação com o sítio receptor, rigidez na molécula, aumento da meia-vida da molécula, prevenção do acesso estérico aos locais de metabolismo e tornar a molécula mais flexível. A principal função do metabolismo de drogas é modificar a estrutura química das drogas para torná-las mais lipofílicas, formar metabólitos com menor lipofilicidade, modificar a estrutura das drogas em metabólitos mais polares e hidrofílicos, causar modificações farmacodinâmicas em drogas inativas e gerar modificações estruturais na droga, formando metabólitos ativos e muitas vezes tóxicos para o organismo.
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