Indicate the amino acid sequence of the atrial natriuretic peptide. Based on your knowledge of how the chemical properties of amino acids influence...
Indicate the amino acid sequence of the atrial natriuretic peptide.
Answer the following questions and justify your answers: a) It is known that the activity of this peptide is highly dependent on variations in the pH of the medium. Explain why. b) Does the primary structure of the atrial natriuretic peptide allow for the formation of salt bridges? Justify. c) Does this peptide have an important alpha-helix region that is likely important for its biological activity? Justify. d) The tertiary structure of this peptide is maintained thanks to a type of interaction between amino acids that does not break even when the peptide is denatured with heat. Explain this fact as well.
a) The activity of the atrial natriuretic peptide is highly dependent on variations in the pH of the medium because changes in pH can alter the charge of the amino acids in the peptide, which can affect its ability to interact with other molecules.
b) The primary structure of the atrial natriuretic peptide does allow for the formation of salt bridges, as it contains amino acids with charged side chains that can interact with each other through electrostatic interactions.
c) Yes, the atrial natriuretic peptide has an important alpha-helix region that is likely important for its biological activity, as alpha-helices are a common structural motif in proteins and can play a role in protein-protein interactions.
d) The tertiary structure of the atrial natriuretic peptide is maintained by disulfide bonds between cysteine residues, which are covalent bonds that are not easily broken even when the peptide is denatured with heat.
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Ed 
A sequência de aminoácidos do peptídeo natriurético atrial é: Ser-Leu-Arg-Arg-Ser-Cys-Phe-Gly-Gly-Arg-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly-Gly-Cys-Gly-Arg-Ile-Gly-Asn-Gly-Leu-Gly
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