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Accepted Manuscript Balance tests in healthy older people Reliability, validity and ability to identify fall status of the BESTest, Mini-BESTest and Brief-BESTest in older people living in the community Alda Marques, PhD, Sara Almeida, MSc, Joana Carvalho, MSc, Joana Cruz, PhD, Ana Oliveira, MSc, Cristina Jácome, PhD PII: S0003-9993(16)30380-X DOI: 10.1016/j.apmr.2016.07.011 Reference: YAPMR 56621 To appear in: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION Received Date: 28 April 2016 Revised Date: 20 June 2016 Accepted Date: 1 July 2016 Please cite this article as: Marques A, Almeida S, Carvalho J, Cruz J, Oliveira A, Jácome C, Balance tests in healthy older people Reliability, validity and ability to identify fall status of the BESTest, Mini- BESTest and Brief-BESTest in older people living in the community, ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2016), doi: 10.1016/j.apmr.2016.07.011. This is a PDF file of an unedited manuscript that has been accepted for publication. 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Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. http://dx.doi.org/10.1016/j.apmr.2016.07.011 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Balance tests in healthy older people Reliability, validity and ability to identify fall status of the BESTest, Mini- BESTest and Brief-BESTest in older people living in the community Alda Marques PhD 1,2, Sara Almeida MSc 1, Joana Carvalho MSc 1, Joana Cruz PhD 1,2, Ana Oliveira MSc 1,2, Cristina Jácome PhD 1 1 Lab 3R – Respiratory Research and Rehabilitation Laboratory, School of Health Sciences, University of Aveiro (ESSUA), Aveiro, Portugal 2 Institute for Research in Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal Acknowledgements: The authors would like to acknowledge the individuals who participated in this study. Funding support: This work was also partially supported by FEDER through COMPETE and FCT under project UID/BIM/04501/2013 and by National Funds through FCT, in the context of the projects UID/CEC/00127/2013 and Incentivo/EEI/UI0127/2014. Conflicts of interest: none. Corresponding author: Alda Marques, PT, MSc, PhD, Senior Lecturer, Lab 3R – Respiratory Research and Rehabilitation Laboratory, School of Health Sciences, University of Aveiro (ESSUA), Agras do Crasto - Campus Universitário de Santiago, Edifício 30, 3810-193 Aveiro, Portugal. Telephone M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT number: 00351 234 372 462. Fax number: 00351 234 401 597. Email: amarques@ua.pt M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 1 Reliability, validity and ability to identify fall status of the BESTest, Mini-1 BESTest and Brief-BESTest in older people living in the community 2 3 Abstract 4 Objective: The reliability, validity and ability to identify fall status of the Balance 5 Evaluation Systems Test (BESTest), Mini-BESTest and Brief-BESTest with the Berg 6 Balance Scale (BBS) in older people living in the community was assessed. 7 Design: Cross-sectional. 8 Setting: Community centers. 9 Participants: 122 older adults (76±9 years) participated. 10 Interventions: Not applicable. 11 Main Outcome Measures: Participants reported on falls history in the preceding 12 year and completed the Activities-specific Balance Confidence (ABC) Scale. BBS, 13 BESTest and the Five times sit-to-stand test were administered. Interrater (two 14 physiotherapists) and test-retest relative (48-72h) and absolute reliability were 15 explored with the Intraclass correlation coefficient (ICC) equation (2,1) and the Bland 16 and Altman method. Minimal detectable changes at the 95% confidence level 17 (MDC95) were established. Validity was assessed by correlating the balance tests 18 with each other and with the ABC Scale (Spearman correlation coefficients - rho). 19 Receiver operating characteristics assessed the ability of each balance test to 20 differentiate between people with and without a history of falls. 21 Results: All balance tests presented good to excellent interrater (ICC 0.71-0.93) and 22 test-retest (ICC 0.50-0.82) relative reliability, with no evidence of bias. MDC95 values 23 were 4.6, 9, 3.8 and 4.1 points for the BBS, BESTest, Mini-BESTest and Brief-24 BESTest, respectively. All tests were significantly correlated with each other 25 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 2 (rho=0.83-0.96) and with the ABC Scale (rho=0.46-0.61). Acceptable ability to 26 identify fall status (areas under the curve 0.71-0.78) was found for all tests. Cut-off 27 points were 48.5, 82, 19.5 and 12.5 points for BBS, BESTest, Mini-BESTest and 28 Brief-BESTest, respectively. 29 Conclusions: All balance tests are reliable, valid and able to identify fall status in 30 older people living in the community therefore, the choice of which test to use will 31 depend on the level of balance impairment, purpose and time availability. 32 33 Key-words: Postural Balance; geriatric assessment; risk assessment; ROC curve. 34 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 3 List of abbreviations 35 ABC Activities-specific Balance Confidence Scale AUC Area under the curve BBS Berg Balance Scale BESTest Balance Evaluation Systems Test COSMIN COnsensus‐based Standards for the selection of health Measurement INstruments GRRAS Guidelines for reliability and agreement studies ICC Intraclass correlation coefficient MDC Minimal detectable changes rho Spearman correlation coefficients SEM Standard error of measurement STROBE STrengthening the Reporting of OBservational studies in Epidemiology 36 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 4 Falls are a major public health problem.1 About a third of community-living older 37 people fall each year.2 For older people living in the community, the human cost of 38 falling includes distress, pain, injury, loss of confidence, and ultimately loss of 39 independence and mortality.3 Therefore, falling has an enormous impact on quality of 40 life and health of community-living older people. Fall prevention programs are 41 currently a worldwide priority1 and to develop such programs it is essential to tackle 42 modifiable fall risk factors. Balance impairment is one of the major modifiable risk 43 factor for falls.4 44 45 Several clinical balance tests are directed at screening for balance impairments and 46 predicting falls. One of the most commonly used tool in clinical situations is the Berg 47 Balance Scale (BBS), which has shown to be reliable, valid,5,6 sensitive and specific 48 in predicting falls in community-based older populations.7 Despite being well-studied, 49 this scale has considerable ceiling effect in various populations,5,8-10 namely in older 50 people living in the community who often represent a population with a higher level of 51 functioning, transmitting the idea that no balance impairment is present, when in fact 52 specific balance training is often warrant. 53 54 Development of balance tests able to identify the underlying systems responsible for 55 balance deficits are critical for health professionals to diagnose specific impairments 56 and develop individualized treatment plans in community-living older people.11 The 57 Balance Evaluation Systems Test (BESTest) was developed to assess functioning of 58 six balance control systems.12 This test has been widely used13-17 however, its 59 administration takes a considerable amount of time (20-30 minutes), which may not 60 be feasible and practicalfor routine clinical use. Thus, two abbreviated versions of 61 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 5 the BESTest, i.e., Mini-BESTest and Brief-BESTest, which take approximately half of 62 the time to be administrated (10-15 minutes), have been developed.18,19 The 63 measurement properties of BESTest,12,13 Mini-BESTest20,21 and Brief-BESTest19 64 have been explored in people with balance disorders and with specific conditions 65 (e.g., Parkinson disease, chronic stoke), however little is known in healthy older 66 people. Recently, construct validity and discriminative ability for older people living in 67 the community have been explored for the BESTest, Mini-BESTest and Brief-68 BESTest22 however, a comparison with BBS was not performed and reliability and 69 cut-offs to differentiate between fallers and non-fallers were not established. 70 71 Therefore, this study aimed to compare the reliability, validity and the ability to 72 identify fall status of the BESTest, the Mini-BESTest and the Brief-BESTest with the 73 BBS in older people living in the community. We hypothesized that all four balance 74 tests will be i) moderately reliable, ii) highly correlated with each other and with self-75 reported balance confidence and iii) able to differentiate between fallers and non-76 fallers. Our secondary aims were to determine the minimal detectable change and 77 propose cut-offs to differentiate between fallers and non-fallers for the same balance 78 tests. 79 80 Methods 81 82 83 Study design and ethics 84 A cross-sectional study was conducted from November 2014 to February 2015 in the 85 central region of Portugal. Ethical approval was obtained from the Ethics Committee 86 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 6 (238/10-2014). This study is reported following the COnsensus‐based Standards for 87 the selection of health Measurement INstruments (COSMIN),23 the STROBE 88 (STrengthening the Reporting of OBservational studies in Epidemiology) statement24 89 and the guidelines for reliability and agreement studies (GRRAS).25 90 91 Participants 92 Fifteen community centers, which main purpose is to promote physical activity and 93 active cognitive functioning of older adults were contacted. Nine agreed to 94 participate, i.e., 2 community activity “clubs”, offering exercises classes, and 7 day 95 care centers, offering a range of recreational, cultural, educational, health and social 96 support services. Staff from the community-centers identified eligible participants 97 according to the following criteria: (i) aged 60 years or older; (ii) living independently 98 in the community and iii) able to ambulate with or without a walking aid (but without 99 the assistance of another person). Individuals were excluded if they i) had 100 comorbidities that interfered with independent ambulation (e.g., hip fracture, lower 101 limb amputation and hemiplegia); ii) were taking medication that could cause 102 dizziness or affect their balance (e.g., psychotropic medications); iii) had self-103 reported cardiorespiratory diseases (e.g., chronic obstructive pulmonary disease, 104 heart failure) or neurological (e.g., Parkinson disease, multiple sclerosis, dementia), 105 musculoskeletal (e.g., severe osteoarthritis) or psychiatric impairments (e.g., 106 psychosis, schizophrenia), that could interfere with the measurements. Individuals 107 were contacted by the researchers, who explained the purpose of the study and 108 asked about their willingness to participate. When individuals agreed to participate, 109 an appointment with the researchers was scheduled at their institution. Written 110 informed consent was obtained prior to data collection. 111 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 7 112 Data collection procedures 113 Socio-demographic (age and gender), anthropometric (height, weight, body mass 114 index) and clinical (self-reported medication and common age-related comorbidities - 115 e.g., hypertension and hyperlipidemia) data were collected. Individuals were provided 116 with a clear definition of falls (an event when you find yourself unintentionally on the 117 ground, floor or lower level)26 and required to report their history of falls using two 118 standardized questions (1. “Have you had any falls in the last 12 months?” and, if 119 yes, 2.“How many times did you fall down in the last 12 months?”).27 The self-120 reported Activities-Specific Balance Confidence (ABC) scale was used to assess 121 balance confidence.28 The ABC Scale quantifies an individual’s perceived ability to 122 maintain his/her balance under different circumstances, using a scale of 0% (no 123 confidence) to 100% (total confidence).29 Then, the BBS, the BESTest and the Five 124 times sit-to-stand test (FTSTS) were performed and participants were encouraged to 125 rest, as needed. Two trained physiotherapists, collected the data. 126 127 For interrater reliability, each of the two physiotherapists performed a simultaneous 128 independent balance assessment at baseline.30,31 For each item of the BBS and of 129 BESTest, one physiotherapist read the instructions to the participant while the other 130 physiotherapist performed the task. Then, the participant performed the task with 131 close supervision. Each task was scored immediately after completion by the two 132 physiotherapists and scoring was not discussed. For test-retest reliability, participants 133 were reassessed by 1 of the 2 physiotherapists after a 48−72h interval. The order of 134 testing was the same. 135 136 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 8 The Mini-BESTest and Brief-BESTest scores were computed based on the 137 performance of the BESTest tasks. A custom designed worksheet was used by the 138 physiotherapists to simultaneously record the BESTest and the Mini-BESTest item 139 scores. Brief-BESTest scores were extracted from the relevant subset of BESTest 140 items. 141 142 Tests 143 Berg Balance scale. The BBS is composed of 14 items to assess performance of 144 specific functional tasks. Each item is scored from 0 (unable to perform) to 4 (normal 145 performance) and the maximum score is 56 points. BBS has been shown to have 146 high interrater and test-retest reliability in personal care home residents32 and in 147 patients with Parkinson disease and stroke.13,33,34 148 149 BESTest. The BESTest contains 36 items organized into 6 subsections: 150 biomechanical constraints, stability limits and verticality, anticipatory postural 151 adjustments, postural responses to external perturbations, sensory orientation during 152 stance and stability in gait.12 Each item is scored from 0 (severe balance impairment) 153 to 3 (no balance impairment) and the maximum possible total score is 108 points. 154 BESTest has high interrater reliability (ICC=0.91-0.99) and test-retest reliability 155 (ICC=0.80-0.99) in subjects with and without balance disorders, in patients with 156 Parkinson disease and in older cancer survivors.12,13,16 Moreover, the BESTest has 157 been found to be accurate in identifying future recurrent fallers in patients with 158 Parkinson disease.35 159 160 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 9 Mini-BESTest. The Mini-BESTest includes 14 items from sections of the BESTest 161 related to anticipatory postural adjustments, reactive postural responses, sensory 162 orientation and stability in gait.18 Two of the 14 items are scored bilaterally. Each item 163 is scored from 0 (severe balance impairment) to 2 (no balance impairment) and the 164 maximum possible score is 28 points. Higher scores indicate better balance 165 performance. In patients with Parkinson disease, the Mini-BESTest test showed high 166 sensitivity (89%)and specificity (81%) in identifying people with abnormal postural 167 responses.36 High interrater (ICC=0.86-0.98) and test-retest reliability (ICC=0.88-168 0.97) have also been found in patients with balance disorders, Parkinson disease, 169 chronic stroke and also in older cancer survivors.16,20,21,31 170 171 Brief-BESTest. The Brief-BESTest is a 6-item balance test, which contains 1 item 172 from each of the 6 subsections of the BESTest.19 Two of the 6 items, are scored 173 bilaterally, resulting in an 8-item balance test. Each item is scored from 0 (severe 174 balance impairment) to 3 (no balance impairment) and the maximum possible score 175 is 24 points. Higher scores indicate better balance performance.19 The Brief-BESTest 176 was accurate in identifying future recurrent fallers in patients with Parkinson 177 disease.35 It has also showed high interrater (ICC=0.86-0.96) and test-retest 178 (ICC=0.90-0.98) reliability in individuals with and without neurological diagnoses19 179 and older cancer survivors.16 180 181 A summary of the core components of each balance test, based on the information 182 provided in the Rehabilitation Measures Database,37 is presented in Supplementary 183 Table 1. 184 (Supplementary table 1) 185 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 10 186 FTSTS 187 The FTSTS was used as a measure of functional mobility.38 Participants started the 188 test in a seated position with their arms folded across their chests and their back 189 against the chair backrest. The following verbal instructions were given: “Please 190 stand up and sit down 5 times as quickly as possible”. Timing (seconds) with a digital 191 stopwatch was initiated manually at the “Go” instruction, and stopped when the 192 subject’s back touched the backrest after the fifth stand. Two trials were performed 193 and the mean of the trials was used in the analysis. This test has shown good 194 intrarater, interrater and test-retest reliability in healthy older adults.39 195 196 Statistical analysis 197 Descriptive statistics were used to describe the sample. A z-test was applied for 198 normality test using skewness and kurtosis.40 Individuals with a history of falls were 199 defined as those who reported at least one fall during the past year; individuals 200 without a history of falls were defined as those who reported no falls during the past 201 year. Participants’ characteristics were compared between those with and without a 202 history of falls, using independent t-tests for normally distributed data, Mann-Whitney 203 U-tests for non-normally distributed and ordinal data and Chi-square tests for 204 categorical data. When significant differences on the performance of balance tests 205 were found between those with and without a history of falls, effect sizes were 206 computed. The Cohen’s d was used as this is the effect size estimate recommended 207 for Independent t-tests.41 Cohen’s d was calculated using the G*Power 3.1 software 208 (University Düsseldorf, Düsseldorf, Germany) and was interpreted as a small (≥0.2), 209 medium (≥0.5), or large (≥0.8) effect.42 The skewness of the distribution of scores 210 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 11 was also assessed for each balance test to verify the occurrence of ceiling and floor 211 effects. A positive skewness value greater than 1 denoted a substantial floor effect 212 and a negative value lower than -1.0 indicated a substantial ceiling effect.43 213 214 Reliability 215 Interrater and test-retest reliability were analyzed in a subsample of the first 216 consecutive 28 participants. This sample size was determined according to the study 217 from Bonnet,44 where it has been established that a sample size of 21 individuals is 218 sufficient to estimate an ICC of 0.9 with a 95% confidence interval width of 0.2 219 (α=0.05 and k=2).44 A 30% attrition rate was estimated, yielding a sample of 28 220 individuals. 221 222 Interrater reliability was computed using the scores obtained from the 2 223 physiotherapists in session 1 and test-retest reliability using the scores from 1 224 physiotherapist in sessions 1 and 2. For relative reliability, the ICC equation (2,1) was 225 used as it was intended to generalize the present results to a variety of raters.45 ICC 226 was interpreted as excellent (>0.75), moderate to good (0.4-0.75) or poor (<0.4).46 227 Absolute reliability was explored with the Bland and Altman method and standard 228 error of measurement (SEM). The Bland and Altman method was used for visual 229 judgement of how well the measurements between raters or sessions agreed.47 230 231 The SEM indicates the extent to which a score varies on repeated measurements. It 232 provides a value for measurement error in the same units as the measurement itself 233 and thus, is easier to use in clinical practice.48 It was calculated using equation 1: 234 ��� = �� �(1 − � ) (1) M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 12 where SD is the standard deviation of the scores obtained from all individuals and 235 ICC is the test-retest reliability coefficient. 236 237 Minimal Detectable Change 238 The MDC at the 95% level of confidence (MDC95), is also reported in the same units 239 as the measurement itself and represents the smallest change that can be 240 interpreted as a real difference. It was calculated as follows (equation 2): 241 �� �� = ��� × 1.96 × √2 (2) The MDC was also expressed as a percentage (MDC%), defined as (equation 3): 242 �� % = (�� �� ����) × 100⁄ (3) where mean is the mean of the scores obtained in the 2 testing sessions. The MDC% 243 is independent of the units of measurement and facilitates the comparison of the 244 random measurement error among different measures.49 A MDC% below 30% is 245 considered acceptable and below 10% excellent.50 246 247 Validity 248 Spearman’s correlation coefficient (rho) was used to examine the relationship among 249 balance tests (concurrent validity) and between each balance test and the ABC Scale 250 (convergent validity). 251 252 Ability to identify fall status 253 Receiver operating characteristic analysis and area under the curves (AUC) and the 254 95% confidence interval were used to determine the cut-off points of each balance 255 test differentiating individuals with and without a history of falls.41 Receiver operating 256 characteristic analysis is a plot of a true-positive rate (sensitivity) and false-positive 257 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 13 rate (1-specificity) across the full range of cut-off scores. The AUC is an index of the 258 diagnostic accuracy of the test. Interpretation of the AUC values was as follow: 259 AUC=0.5 no discrimination; 0.7≤AUC<0.8 acceptable discrimination; 0.8≤AUC<0.9 260 excellent discrimination and AUC≥0.9 outstanding discrimination.51 The optimal cut-261 off value for each balance test to differentiate between individuals with and without a 262 history of falls was chosen as the intersection point which maximized both, sensitivity 263 and specificity values. 264 265 All statistical analyses were performed using IBM SPSS Statistics version 20.0 (IBM 266 Corporation, Armonk, NY, USA) and plots created using GraphPad Prism version 267 5.01 (GraphPad Software, Inc., La Jolla, CA, USA). The level of significance was set 268 at 0.05. 269 270 Results 271 272 273 Participants 274 A total of 130 individuals were invited to participate. However, 8 refused to complete 275 the assessment. Therefore, 122 participants were included. Participants were mainly 276 female (n=86; 70.5%), with a mean age of 76±9 years old. Thirteen participants used 277 walking aids, eleven used a cane and two used a walker. Participants’ characteristics278 and balance scores are presented in Table 1. 279 (table 1) 280 281 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 14 Skewness of BESTest (-0.62), Mini-BESTest (-0.67) and Brief-BESTest (-0.40) were 282 lower than the BBS (-1.46). 283 284 Reliability and Minimal Detectable Change 285 Table 2 presents the relative and absolute interrater and test-retest reliability results. 286 Moderate to good interrater relative reliability was observed for the Mini-BESTest 287 (ICC 0.71), while the other balance tests presented excellent interrater relative 288 reliability (ICC from 0.86 to 0.93). The Bland and Altman method also showed good 289 agreement between the two physiotherapists, with small mean differences (from - 290 0.1±1.1 to 0.4±3.5) for all balance tests (Table 2). BBS (ICC=0.50) and Mini-BESTest 291 had moderate to good (ICC=0.73) whereas BESTest and Brief-BESTest had 292 excellent (ICC of 0.77 and 0.82) relative test-retest reliability (Table 2). 293 (table 2) 294 295 The MDC95 was 4.6 (SEM=1.7 MDC%=8.6%), 9 (SEM=3.3; MDC%=10.2%), 3.8 296 (SEM=1.4; MDC%=16.3%) and 4.1 (SEM=1.5; MDC%=21.5%) points for BBS, 297 BESTest, Mini-BESTest and Brief-BESTest, respectively. 298 299 Validity 300 All balance tests were strongly correlated with each other (rho ranged from 0.83-301 0.96; p<0.001). Scores of the ABC Scale were also significantly correlated with the 302 scores of BBS (rho=0.58; p<0.001), BESTest (rho=0.46; p<0.001), Mini-BESTest 303 (rho=0.57; p<0.001) and Brief-BESTest (rho=0.61; p<0.001). 304 305 Ability to identify fall status 306 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 15 Thirty four participants (27.9%) had a history of falls and were significantly older than 307 those without a history of falls (Table 1). The FTSTS and balance tests were able to 308 significantly differentiate between participants with and without a history of falls 309 (p<0.007) (Table 1). Large effect sizes were found for BBS (Cohen’s d =1.00), 310 BESTest (Cohen’s d =0.81), Mini-BESTest (Cohen’s d =1.02) and Brief-BESTest 311 (Cohen’s d =1.00). 312 313 Table 3 presents the results from the receiver operating characteristic analysis. 314 Balance tests had acceptable ability to differentiate participants with and without a 315 history of falls (AUC from 0.71 to 0.78). Sensitivity to differentiate fall status was 316 similar across balance tests (71-74%). Specificity, however, was higher for the Brief- 317 BESTest (76%), Mini-BESTest (71%) and BBS (72%) than for BESTest (67%). The 318 identified cut-offs are 48.5 points for BBS, 82 points for BESTest, 19.5 points for 319 Mini-BESTest and 12.5 points for Brief-BESTest (Table 3). Figure 1 illustrates the 320 AUC as well as the identified cut-off points. 321 322 (table 3 and Figure 1) 323 324 Discussion 325 326 327 This study showed that the four balance tests presented good to excellent inter-rater 328 and test-retest reliability, were highly correlated with each other (concurrent validity) 329 and with the self-reported balance confidence (convergent validity), and were able to 330 differentiate between older people living in the community with and without a history 331 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 16 of falls with similar sensitivity/specificity. Therefore, findings support the use of all 332 tests to assess balance impairment. However, similar to previous studies the BBS 333 presented a substantial ceiling effect.8,36 Thus it may be more appropriate for health 334 professionals to use the BESTest and its short versions to assess balance in older 335 people living in the community. 336 337 Although the reliability of the BBS has been widely studied,5,8 much less is known 338 about the BESTest and its short versions. This study showed that the BBS, BESTest, 339 Mini-BESTest and Brief-BESTest have good to excellent interrater (ICC 0.71-0.93) 340 and test-retest (ICC 0.50-0.82) relative reliability in older people living in the 341 community. Similar findings have been reported for relative reliability of BESTest and 342 its short versions in other studied populations.13,16,19-21 343 344 Absolute reliability has been much less studied than relative reliability despite the 345 GRRAS guidelines25 recommendations to study both. In this study, balance tests 346 showed good agreement with no systematic bias between raters and sessions, with 347 relatively small SEM. Although, the Bland and Altman method has not been 348 commonly used for visual inspection of BESTest and its short versions, some studies 349 have reported the SEM for BESTest,16 Mini-BESTest16,20 and Brief-BESTest.16 The 350 SEM is largely independent of the population from which it is determined however, its 351 calculation depends of the standard deviation of the scores from all individuals 352 studied.48 In this study, the standard deviations of BESTest and its short versions 353 were higher than those already reported when studying patients with balance 354 disorders or older cancer survivors, thus higher values of SEM have been found 355 (BESTest - 3.3 vs 1.75;16 Mini-BESTest – 1.4 vs 1.2216 or 1.26;20 Brief-BESTest – 1.5 356 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 17 vs 1.1316). Nevertheless, these SEM differences might not be of clinical relevance 357 considering the score range of the balance tests assessed and the achieved changes 358 (considerably higher than the SEM values here reported) in studies conducting 359 balance training.20,52 Nevertheless, results should be interpreted with caution as 360 absolute reliability has been little studied in BESTest and its short versions. Future 361 studies exploring both types of reliability are needed. 362 363 In this study, acceptable values of MDC% and MDC95 values were found. Higher 364 MDC95 (6.5 53 and 6.220) have been reported for BBS however, in this study, a sample 365 of healthy older people were studied and a substantial ceiling effect for the BBS was 366 found, which may explain the lower MDC95 found. For BESTest and its short versions 367 no ceiling or floor effects were observed and all MDC95 values were higher than 368 those previously published.15,16,20,21 However, these studies were conducted with 369 patients with specific health conditions, such as chronic stroke, total knee 370 arthroplasty, balance disorders and history of cancer.15,16,20,21 Therefore, it is not 371 surprising that higher MDC95 values were found in a healthy older population. 372 Therefore, the MDC95 established in this study will be useful for health professionals 373 working with older people living in the community in determining whether an 374 intervention (e.g., fall prevention program) has caused any real change in balance 375 ability. 376 377 Similarly to other studies,16,20-22 all balance tests were significantly correlated with 378 each other and with the ABC scale, indicating good concurrent and convergent 379 validity. All balance tests were also able to significantly differentiate between 380 participants with and without a history of falls with large effect sizes, acceptable 381 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 18 ability and similar sensitivity and specificity. The cut-off points identified were similar 382 to those previously published for BBS,36 BESTest,35 Mini-BESTest35,36 and Brief-383 BESTest35. These cut-off scores indicate the level of balance impairment that is 384 associated with falling. This is especially important for health professionals to detect 385 fall risk in older adults before a fall occurs and implement preventive effective 386 interventions. 387 388 Study Limitations 389 The sample included older people living in the community, which limits the390 generalizability of the results to the overall older population. It is unclear whether the 391 participation in community centers activities have contributed to minimize the risk of 392 falling. Future studies could compare the balance impairment and risk of falling 393 between older people integrating and not integrating community centers in order to 394 clarify these issues. Older people living in the community were classified as having or 395 not having a history of falls based on their self-report hence, some degree of bias in 396 their responses might have been present. Moreover, tasks that were similar among 397 BESTest, Mini-BESTest and Brief-BESTest were only performed once and therefore, 398 this influenced the correlation results. Future studies should assess the reliability, 399 validity and ability to identify fall status of the Mini-BESTest and of the Brief-BESTest 400 when performed separately from the BESTest. Finally, as this was a cross-sectional 401 study, the ability of the balance tests to identify fall status in older people living in the 402 community was analyzed retrospectively. Longitudinal studies should be conducted 403 in order to assess the ability of these tests in identifying recurrent fallers 404 prospectively. 405 406 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 19 Conclusions 407 408 409 BBS, BESTest, Mini-BESTest and Brief-BESTest are highly reliable, valid and able to 410 differentiate between older people living in the community with and without a history 411 of falls. However, as BBS presented a substantial ceiling effect, BESTest and its 412 short versions seem more appropriate to assess specific balance impairments in 413 older people living in the community. MDC95 values and cut-off points for BBS, 414 BESTest, Mini-BESTest and Brief-BESTest, were established. 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Minimum detectable change of the 574 Berg Balance Scale and Dynamic Gait Index in older persons at risk for falling. 575 J Geriatr Phys Ther. 2011;34(3):131-137. 576 577 578 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 27 Figure captions 579 Figure 1 - Receiver operator characteristics of the Berg Balance Scale (BBS), 580 Balance Evaluation Systems Test (BESTest), Mini-BESTest and the Brief-BESTest 581 to differentiate participants with and without a history of falls (n=122). 582 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Table 1 - Participants’ characteristics and balance scores (n=122). Characteristics Total (n=122) Without a history of falls (n=88) With a history of falls (n=34) p-value Age (years) 75.9 ± 8.9 74.7 ± 8.8 78.9 ± 8.6 0.020 Gender Female 86 (70.5%) 58 (65.9%) 28 (82.4%) 0.081 Male 36 (29.5%) 30 (34.1%) 6 (17.6%) BMI (Kg/m2) 26.8 ± 4 26.9 ± 4 26.6 ± 4.2 0.715 Walking aid 13 (10.7%) 7 (8%) 6 (17.6%) 0.187 Comorbidities, M[IQR] 2 [1, 3] 1.5 [1, 3] 2 [1, 3] 0.573 ABC scale 80.9 ± 22.1 86.6 ± 17.7 66.1 ± 25.4 <0.001 FTSTS (seconds) 12.9 ± 5 12.2 ± 4.4 15 ± 6.1 0.007 BBS 47.2 ± 10 49.9 ± 8.3 40.2 ± 10.9 <0.001 BESTest 84.7 ± 24.5 84 ± 13.9 71.7 ± 16.5 <0.001 Mini-BESTest 19.8 ± 6.8 21.6 ± 5.8 15 ± 7.1 <0.001 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Note: values show mean ± SD or n(%) unless otherwise indicated. Abbreviations: ABC, Activities-Specific Balance Confidence; BBS, Berg Balance Scale, BESTest, Balance Evaluation Systems Test; BMI, body mass index; FTSTS, Five times sit-to-stand test; M, median; IQR, interquartile range. Brief-BESTest 14.3 ± 6.8 16 ± 6 9.7 ± 6.6 <0.001 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Table 2 – Interrater and test-retest reliability of the Berg Balance Scale (BBS), Balance Evaluation Systems Test (BESTest), Mini- BESTest and Brief-BESTest (n=28). Interrater reliability Test-retest reliability Balance test ICC (95% CI) MD±SD 95% LA ICC (95% CI) MD±SD 95% LA BBS 0.88 (0.77→0.94) -0.1 ± 1.1 -2.2→2 0.50 (0.15→0.73) -0.7 ± 2 -4.6→3.2 BESTest 0.86 (0.73→0.92) 0.4 ± 3.5 -6.5→7.2 0.77 (0.55→0.88) -1.6 ± 4.3 -10.1→6.9 Mini-BESTest 0.71 (0.50→0.84) -0.2 ± 2 -4.2→3.7 0.73 (0.49→0.86) -0.4 ± 1.9 -4.2→3.3 Brief-BESTest 0.93 (0.87→0.97) -0.2 ± 1.2 -2.5→2.1 0.82 (0.65→0.91) -0.4 ± 2 -4.4→3.5 Abbreviations: 95% CI, 95% confidence intervals; ICC, Intraclass Correlation Coefficient; 95% LA, 95% limits of agreement; MD, mean difference; SD, standard deviation. M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Table 3 – Ability of the Berg Balance Scale (BBS), Balance Evaluation Systems Test (BESTest), Mini-BESTest and Brief-BESTestto identify fall status (n=122). Abbreviations: AUC, area under the curve; 95%CI, 95% confidence intervals; SEM, standard error. Balance test AUC (SEM) 95% CI Cut-off point % Sensitivity / % Specificity Positive / Negative Likelihood Ratios BBS 0.78 (0.05) 0.68→0.87 48.5 74 / 72 2.59 / 0.37 BESTest 0.71 (0.06) 0.60→0.82 82 74 / 67 2.23 / 0.40 Mini-BESTest 0.76 (0.05) 0.66→0.86 19.5 74 / 71 2.49 / 0.38 Brief-BESTest 0.76 (0.05) 0.66→0.86 12.5 71 / 76 2.92 / 0.39 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Highlights • BBS, BESTest, Mini-BESTest and Brief-BESTest are reliable in older people living in the community. • MDC values were established for the BBS, BESTest, Mini-BESTest and Brief-BESTest. • The four balance tests are able to differentiate between community-living older people with and without a history of falls • Test selection depends on balance impairment level, purpose and time availability. M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Supplementary Table 1 – Summary of the core components of each balance test. Balance test Number of items Scoring Maximum score Time to Administer Populations tested BBS 14 0-4 56 15-20 min Brain injury Cerebral palsy Chronic Obstructive Pulmonary Disease Community-living older adults Lower-limb amputation Multiple sclerosis Older people living in residential care facilities Orthopedic Surgery Osteoarthritis Parkinson Disease Spinal Cord Injury Stroke Total knee arthroplasty Traumatic and acquired brain injury Vestibular Dysfunction BESTest 36 0-3 108 20-30 min Balance deficits Cancer survivors Cerebellar Infarct Chronic Obstructive Pulmonary Disease Community-living older adults Multiple Sclerosis Parkinson Disease Peripheral neuropathy Stroke Total knee arthroplasty Vestibular dysfunction M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Mini- BESTest 14 0-2 28 10-15 min Age-Related Balance Disorders Ataxia Cancer survivors Cervical Myelopathy Chronic Obstructive Pulmonary Disease CNS Neoplasm Community-living older adults Multiple Sclerosis Neuromuscular Disease Nontraumatic Brain Injury Parkinson Disease Peripheral neuropathy Peripheral Vestibular Disorders Spinal cord injury Stroke Total knee arthroplasty Traumatic Brain Injury Wolfram syndrome Brief- BESTest 6 0-3 24 10 min Cancer survivors Chronic Obstructive Pulmonary Disease Community-living older adults Multiple Sclerosis Parkinson Disease Peripheral Neuropathy Stroke Total knee arthroplasty
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